Early detection of osteoarthritis in the rat with an antibody specific to type II collagen modified by reactive oxygen species

Early detection of osteoarthritis in the rat with an antibody specific to type II collagen modified by reactive oxygen species

Abstract Background Osteoarthritis (OA) is a disease of the whole joint, with articular cartilage breakdown as a major characteristic. Inflammatory mediators, proteases, and oxidants produced by chondrocytes are known to be responsible for driving cartilage degradation. Nevertheless, the early patho...

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Bibliographic Details
Main Authors: Anne Gigout, Donata Harazin, Louise M. Topping, Didier Merciris, Sven Lindemann, Christian Brenneis, Ahuva Nissim
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Arthritis Research & Therapy
Subjects:
Reactive oxygen species
Osteoarthritis
Hypertrophy
Collagen type II
Collagen type X
Online Access:https://doi.org/10.1186/s13075-021-02502-1

Internet

https://doi.org/10.1186/s13075-021-02502-1

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