Cell-cycle-gated feedback control mediates desensitization to interferon stimulation

Cell-cycle-gated feedback control mediates desensitization to interferon stimulation

Cells use molecular circuits to interpret and respond to extracellular cues, such as hormones and cytokines, which are often released in a temporally varying fashion. In this study, we combine microfluidics, time-lapse microscopy, and computational modeling to investigate how the type I interferon (...

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Bibliographic Details
Main Authors: Anusorn Mudla, Yanfei Jiang, Kei-ichiro Arimoto, Bingxian Xu, Adarsh Rajesh, Andy P Ryan, Wei Wang, Matthew D Daugherty, Dong-Er Zhang, Nan Hao
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-09-01
Series:eLife
Subjects:
interferons
desensitization
signal dynamics
single-cell analysis
time-lapse microscopy
computational modeling
Online Access:https://elifesciences.org/articles/58825

Internet

https://elifesciences.org/articles/58825

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