Optical vagus nerve modulation of heart and respiration via heart-injected retrograde AAV

Abstract Vagus nerve stimulation has shown many benefits for disease therapies but current approaches involve imprecise electrical stimulation that gives rise to off-target effects, while the functionally relevant pathways remain poorly understood. One method to overcome these limitations is the use...

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Bibliographic Details
Main Authors: Arjun K. Fontaine, Gregory L. Futia, Pradeep S. Rajendran, Samuel F. Littich, Naoko Mizoguchi, Kalyanam Shivkumar, Jeffrey L. Ardell, Diego Restrepo, John H. Caldwell, Emily A. Gibson, Richard F. ff Weir
Format: Article
Language:English
Published: Nature Publishing Group 2021-02-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-83280-3