An in vitro toolbox to accelerate anti-malarial drug discovery and development

An in vitro toolbox to accelerate anti-malarial drug discovery and development

Abstract Background Modelling and simulation are being increasingly utilized to support the discovery and development of new anti-malarial drugs. These approaches require reliable in vitro data for physicochemical properties, permeability, binding, intrinsic clearance and cytochrome P450 inhibition....

Full description

Bibliographic Details
Main Authors: Susan A. Charman, Alice Andreu, Helena Barker, Scott Blundell, Anna Campbell, Michael Campbell, Gong Chen, Francis C. K. Chiu, Elly Crighton, Kasiram Katneni, Julia Morizzi, Rahul Patil, Thao Pham, Eileen Ryan, Jessica Saunders, David M. Shackleford, Karen L. White, Lisa Almond, Maurice Dickins, Dennis A. Smith, Joerg J. Moehrle, Jeremy N. Burrows, Nada Abla
Format: Article
Language:English
Published: BMC 2020-01-01
Series:Malaria Journal
Subjects:
Physiologically-based pharmacokinetic modelling
Anti-malarial drugs
Ionization constant
Partition coefficient
Biorelevant solubility
Protein binding
Online Access:https://doi.org/10.1186/s12936-019-3075-5

Internet

https://doi.org/10.1186/s12936-019-3075-5

Similar Items