Clinical Predictors of Early Trial Discontinuation for Patients Participating in Phase I Clinical Trials in Oncology

Clinical Predictors of Early Trial Discontinuation for Patients Participating in Phase I Clinical Trials in Oncology

Despite stringent eligibility criteria for trial participation, early discontinuation often occurs in phase I trials. To better identify patients unlikely to benefit from phase I trials, we investigated predictors for early trial discontinuation. Data from 415 patients with solid tumors who particip...

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Bibliographic Details
Main Authors: Joeri A. J. Douma, Laurien M. Buffart, Ramy Sedhom, Mariette Labots, Willemien C. Menke-van der Houven van Oordt, Mikkjal Skardhamar, Anthony De Felice, Esther Lee, Divya Dharmaraj, Nilofer S. Azad, Michael A. Carducci, Henk M. W. Verheul
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Cancers
Subjects:
phase I trial
drug development
early trial discontinuation
clinical predictors
hyponatremia
Online Access:https://www.mdpi.com/2072-6694/13/10/2304

Internet

https://www.mdpi.com/2072-6694/13/10/2304

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