Anti-Double-Stranded DNA IgG Participates in Renal Fibrosis through Suppressing the Suppressor of Cytokine Signaling 1 Signals

Anti-Double-Stranded DNA IgG Participates in Renal Fibrosis through Suppressing the Suppressor of Cytokine Signaling 1 Signals

Suppressor of cytokine signaling 1 (SOCS1) participates in renal fibrosis by downregulating Janus kinase 2 (JAK2)/signal transducer and activator of transcription 1 (STAT1)-mediated cytokine signaling. Recently, it was found that anti-double-stranded DNA (dsDNA) IgG induces the synthesis of profibro...

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Bibliographic Details
Main Authors: Ping Wang, Jie Yang, Fang Tong, Zhaoyang Duan, Xingyin Liu, Linlin Xia, Ke Li, Yumin Xia
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-05-01
Series:Frontiers in Immunology
Subjects:
anti-double-stranded DNA IgG
suppressor of cytokine signaling 1
Janus kinase 2
signal transducer and activator of transcription 1
peptide
lupus nephritis
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00610/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.00610/full

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