Exosomes Derived From Alveolar Epithelial Cells Promote Alveolar Macrophage Activation Mediated by miR-92a-3p in Sepsis-Induced Acute Lung Injury

Exosomes Derived From Alveolar Epithelial Cells Promote Alveolar Macrophage Activation Mediated by miR-92a-3p in Sepsis-Induced Acute Lung Injury

Acute lung injury (ALI) induced by sepsis is characterized by disruption of the epithelial barrier and activation of alveolar macrophages (AMs), which leads to uncontrolled pulmonary inflammation. However, effective treatments for ALI are unavailable. The exact mechanism by which the initial mediato...

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Bibliographic Details
Main Authors: Fen Liu, Wei Peng, Jiaquan Chen, Zeyao Xu, Rong Jiang, Qiang Shao, Ning Zhao, Kejian Qian
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
sepsis
acute lung injury
exosomes
miR-92a-3p
alveolar macrophage
alveolar epithelial cells
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2021.646546/full

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https://www.frontiersin.org/articles/10.3389/fcimb.2021.646546/full

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