Transcriptional CDK inhibitors, CYC065 and THZ1 promote Bim-dependent apoptosis in primary and recurrent GBM through cell cycle arrest and Mcl-1 downregulation

Transcriptional CDK inhibitors, CYC065 and THZ1 promote Bim-dependent apoptosis in primary and recurrent GBM through cell cycle arrest and Mcl-1 downregulation

Abstract Activation of cyclin-dependent kinases (CDKs) contributes to the uncontrolled proliferation of tumour cells. Genomic alterations that lead to the constitutive activation or overexpression of CDKs can support tumourigenesis including glioblastoma (GBM), the most common and aggressive primary...

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Bibliographic Details
Main Authors: Viktorija Juric, Lance Hudson, Joanna Fay, Cathy E. Richards, Hanne Jahns, Maïté Verreault, Franck Bielle, Ahmed Idbaih, Martine L. M. Lamfers, Ann M. Hopkins, Markus Rehm, Brona M. Murphy
Format: Article
Language:English
Published: Nature Publishing Group 2021-08-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-021-04050-7

Internet

https://doi.org/10.1038/s41419-021-04050-7

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