MiR-93 Controls Adiposity via Inhibition of Sirt7 and Tbx3

MiR-93 Controls Adiposity via Inhibition of Sirt7 and Tbx3

Conquering obesity has become a major socioeconomic challenge. Here, we show that reduced expression of the miR-25-93-106b cluster, or miR-93 alone, increases fat mass and, subsequently, insulin resistance. Mechanistically, we discovered an intricate interplay between enhanced adipocyte precursor tu...

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Bibliographic Details
Main Authors: Michele Cioffi, Mireia Vallespinos-Serrano, Sara M. Trabulo, Pablo Jose Fernandez-Marcos, Ashley N. Firment, Berta N. Vazquez, Catarina R. Vieira, Francesca Mulero, Juan A. Camara, Ultan P. Cronin, Manuel Perez, Joaquim Soriano, Beatriz G. Galvez, Alvaro Castells-Garcia, Verena Haage, Deepak Raj, Diego Megias, Stephan Hahn, Lourdes Serrano, Anne Moon, Alexandra Aicher, Christopher Heeschen
Format: Article
Language:English
Published: Elsevier 2015-09-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124715008621

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http://www.sciencedirect.com/science/article/pii/S2211124715008621

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