In vitro Radiopharmaceutical Evidence for MCHR1 Binding Sites in Murine Brown Adipocytes

In vitro Radiopharmaceutical Evidence for MCHR1 Binding Sites in Murine Brown Adipocytes

[11C]SNAP-7941 and its radiofluorinated, fluoro-ethyl derivative [18F]FE@SNAP have been developed as the first positron emission tomography tracers for melanin-concentrating hormone receptor 1 (MCHR1) imaging. Accumulation of these MCHR1 PET-tracers in rat brown adipose tissue (BAT) in vivo provided...

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Bibliographic Details
Main Authors: Theresa Balber, Katarína Benčurová, Florian Wolfgang Kiefer, Oana Cristina Kulterer, Eva-Maria Klebermass, Gerda Egger, Loan Tran, Karl-Heinz Wagner, Helmut Viernstein, Katharina Pallitsch, Helmut Spreitzer, Marcus Hacker, Wolfgang Wadsak, Markus Mitterhauser, Cécile Philippe
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Endocrinology
Subjects:
melanin-concentrating hormone receptor 1
MCHR1
brown adipocytes
BAT
adrenergic beta-3 receptor
[18F]FE@SNAP
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2019.00324/full

Internet

https://www.frontiersin.org/article/10.3389/fendo.2019.00324/full

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