Dynamic epigenetic control of highly conserved noncoding elements.

Many noncoding genomic loci have remained constant over long evolutionary periods, suggesting that they are exposed to strong selective pressures. The molecular functions of these elements have been partially elucidated, but the fundamental reason for their extreme conservation is still unknown.To g...

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Bibliographic Details
Main Authors: Loqmane Seridi, Taewoo Ryu, Timothy Ravasi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4188601?pdf=render