Induction and decay of functional complement-fixing antibodies by the RTS,S malaria vaccine in children, and a negative impact of malaria exposure

Induction and decay of functional complement-fixing antibodies by the RTS,S malaria vaccine in children, and a negative impact of malaria exposure

Abstract Background Leading malaria vaccine, RTS,S, is based on the circumsporozoite protein (CSP) of sporozoites. RTS,S confers partial protection against malaria in children, but efficacy wanes relatively quickly after primary immunization. Vaccine efficacy has some association with anti-CSP IgG;...

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Bibliographic Details
Main Authors: Liriye Kurtovic, Paul A. Agius, Gaoqian Feng, Damien R. Drew, Itziar Ubillos, Jahit Sacarlal, John J. Aponte, Freya J. I. Fowkes, Carlota Dobaño, James G. Beeson
Format: Article
Language:English
Published: BMC 2019-02-01
Series:BMC Medicine
Subjects:
Antibody function
Circumsporozoite protein
Complement
Malaria
Plasmodium falciparum
RTS,S
Online Access:http://link.springer.com/article/10.1186/s12916-019-1277-x

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http://link.springer.com/article/10.1186/s12916-019-1277-x

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