Mice deficient in dihydrolipoyl succinyl transferase show increased vulnerability to mitochondrial toxins

Mice deficient in dihydrolipoyl succinyl transferase show increased vulnerability to mitochondrial toxins

The activity of a key mitochondrial tricarboxylic acid cycle enzyme, α-ketoglutarate dehydrogenase complex (KGDHC), declines in many neurodegenerative diseases. KGDHC consists of three subunits. The dihydrolipoyl succinyl transferase (DLST) component is unique to KGDHC. DLST+/− mice showed reduced m...

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Bibliographic Details
Main Authors: Lichuan Yang, Qingli Shi, Daniel J. Ho, Anatoly A. Starkov, Elizabeth J. Wille, Hui Xu, H.L. Chen, Steven Zhang, Cliona M. Stack, Noel Y. Calingasan, Gary E. Gibson, M. Flint Beal
Format: Article
Language:English
Published: Elsevier 2009-11-01
Series:Neurobiology of Disease
Subjects:
Mitochondria
Neurodegenerative diseases
Parkinson
Huntington
Oxidative damage
α-ketoglutarate dehydrogenase complex
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996109002034

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http://www.sciencedirect.com/science/article/pii/S0969996109002034

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