QSAR, Molecular Docking and protein ligand interaction fingerprint studies of N-phenyl dichloroacetamide derivatives as anticancer agents
Dichloroacetate (DCA) is a pyruvate mimetic compound that stimulates the activity of the enzyme pyruvate dehydrogenase (PDH) through inhibition of the enzyme pyruvate dehydrogenase kinases (PDK1-4). DCA works by turning on the apoptosis which is suppressed in tumor cells, hence let them to die on th...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Shiraz University of Medical Sciences
2016-06-01
|
Series: | Trends in Pharmaceutical Sciences |
Subjects: | |
Online Access: | https://tips.sums.ac.ir/article_42195_072396b245b96fd805158616da82a912.pdf |