Potential modulation on BCRP and MRP 4 by onion: in vivo and ex-vivo studies
Onion skin contains quercetin, kaempferol and their glycosides. Methotrexate (MTX), an immunosuppressant with narrow therapeutic window, is used as a probe substrate of BCRP and MRP 4. This study investigated the effect of onion skin powder (OSP) on MTX pharmacokinetics. Rats were orally administere...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2014-05-01
|
| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464614001224 |