Integrated genomic analysis implicates haploinsufficiency of multiple chromosome 5q31.2 genes in de novo myelodysplastic syndromes pathogenesis.

Integrated genomic analysis implicates haploinsufficiency of multiple chromosome 5q31.2 genes in de novo myelodysplastic syndromes pathogenesis.

Deletions spanning chromosome 5q31.2 are among the most common recurring cytogenetic abnormalities detectable in myelodysplastic syndromes (MDS). Prior genomic studies have suggested that haploinsufficiency of multiple 5q31.2 genes may contribute to MDS pathogenesis. However, this hypothesis has nev...

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Bibliographic Details
Main Authors: Timothy A Graubert, Michelle A Payton, Jin Shao, Richard A Walgren, Ryan S Monahan, John L Frater, Mark A Walshauser, Mike G Martin, Yumi Kasai, Matthew J Walter
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2642994?pdf=render

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http://europepmc.org/articles/PMC2642994?pdf=render

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