Reduced Calcium Signaling Is Associated With Severe Graft-Versus-Host Disease: Results From Preclinical Models and From a Prospective EBMT Study

Reduced Calcium Signaling Is Associated With Severe Graft-Versus-Host Disease: Results From Preclinical Models and From a Prospective EBMT Study

Despite its involvement in various immune functions, including the allogeneic activation of T-lymphocytes, the relevance of calcium (Ca2+) for GVHD pathobiology is largely unknown. To elucidate a potential association between Ca2+and GVHD, we analyzed Ca2+-sensing G-protein coupled receptor 6a (GPRC...

Full description

Bibliographic Details
Main Authors: Katarina Riesner, Steffen Cordes, Christophe Peczynski, Martina Kalupa, Constanze Schwarz, Yu Shi, Sarah Mertlitz, Jörg Mengwasser, Steffie van der Werf, Zinaida Peric, Christian Koenecke, Helene Schoemans, Rafael F. Duarte, Grzegorz W. Basak, Olaf Penack
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Immunology
Subjects:
graft-versus-host-disease
stem cell transplantation
calcium
GPRC6a
GVHD mouse models
EBMT study
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01983/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.01983/full

Similar Items