Bmp6 expression in murine liver non parenchymal cells: a mechanism to control their high iron exporter activity and protect hepatocytes from iron overload?

Bmp6 expression in murine liver non parenchymal cells: a mechanism to control their high iron exporter activity and protect hepatocytes from iron overload?

Bmp6 is the main activator of hepcidin, the liver hormone that negatively regulates plasma iron influx by degrading the sole iron exporter ferroportin in enterocytes and macrophages. Bmp6 expression is modulated by iron but the molecular mechanisms are unknown. Although hepcidin is expressed almost...

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Bibliographic Details
Main Authors: Marco Rausa, Alessia Pagani, Antonella Nai, Alessandro Campanella, Maria Enrica Gilberti, Pietro Apostoli, Clara Camaschella, Laura Silvestri
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4393274?pdf=render

Internet

http://europepmc.org/articles/PMC4393274?pdf=render

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