Tris-hydroxymethyl-aminomethane enhances capsaicin-induced intracellular Ca2+ influx through transient receptor potential V1 (TRPV1) channels

Tris-hydroxymethyl-aminomethane enhances capsaicin-induced intracellular Ca2+ influx through transient receptor potential V1 (TRPV1) channels

Non-selective transient receptor potential vanilloid (TRPV) cation channels are activated by various insults, including exposure to heat, acidity, and the compound capsaicin, resulting in sensations of pain in the skin, visceral organs, and oral cavity. Recently, TRPV1 activation was also demonstrat...

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Bibliographic Details
Main Authors: Satoshi Murakami, Yuka Sudo, Kanako Miyano, Hitomi Nishimura, Motohiro Matoba, Seiji Shiraishi, Hiroki Konno, Yasuhito Uezono
Format: Article
Language:English
Published: Elsevier 2016-02-01
Series:Journal of Pharmacological Sciences
Subjects:
Calcium signaling
Nociceptive pain
Tris-hydroxymethyl aminomethane (THAM)
TRPV cation channels
TRPV1 receptor
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861315002315

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http://www.sciencedirect.com/science/article/pii/S1347861315002315

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