A nonsense mutation in TLR5 is associated with survival and reduced IL-10 and TNF-α levels in human melioidosis.

A nonsense mutation in TLR5 is associated with survival and reduced IL-10 and TNF-α levels in human melioidosis.

Melioidosis, caused by the flagellated bacterium Burkholderia pseudomallei, is a life-threatening and increasingly recognized emerging disease. Toll-like receptor (TLR) 5 is a germline-encoded pattern recognition receptor to bacterial flagellin. We evaluated the association of a nonsense TLR5 geneti...

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Bibliographic Details
Main Authors: Panjaporn Chaichana, Narisara Chantratita, Florian Brod, Sirikamon Koosakulnirand, Kemajittra Jenjaroen, Suchintana Chumseng, Manutsanun Sumonwiriya, Mary N Burtnick, Paul J Brett, Prapit Teparrukkul, Direk Limmathurotsakul, Nicholas P J Day, Susanna J Dunachie, T Eoin West
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-05-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC5435357?pdf=render

Internet

http://europepmc.org/articles/PMC5435357?pdf=render

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