Lights on for HIF-1α: Genetically Enhanced Mouse Cardiomyocytes for Heart Tissue Imaging

Lights on for HIF-1α: Genetically Enhanced Mouse Cardiomyocytes for Heart Tissue Imaging

Background/Aims: The hypoxia inducible factor-1 (HIF-1) is a suitable marker for tissue oxygenation. We intended to develop cardiomyocytes (CMs) expressing the oxygen-dependent degradation domain of HIF-1α fused to the firefly luciferase (ODD-Luc) followed by proof-of-concept for its applicability i...

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Bibliographic Details
Main Authors: Amke R. Hesse, Elif Levent, Anke Zieseniss, Malte Tiburcy, Wolfram H. Zimmermann, Dörthe M. Katschinski
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2014-07-01
Series:Cellular Physiology and Biochemistry
Subjects:
Hypoxia
Oxygenation
Engineered heart muscle
HIF-1α
Online Access:http://www.karger.com/Article/FullText/363014

Internet

http://www.karger.com/Article/FullText/363014

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