Time dependent hazard ratio estimation using instrumental variables without conditioning on an omitted covariate

Abstract Background Estimation that employs instrumental variables (IV) can reduce or eliminate bias due to confounding. In observational studies, instruments result from natural experiments such as the effect of clinician preference or geographic distance on treatment selection. In randomized studi...

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Bibliographic Details
Main Authors: Todd A. MacKenzie, Pablo Martinez-Camblor, A. James O’Malley
Format: Article
Language:English
Published: BMC 2021-03-01
Series:BMC Medical Research Methodology
Subjects:
Online Access:https://doi.org/10.1186/s12874-021-01245-6