Efficient clofilium tosylate-mediated rescue of POLG-related disease phenotypes in zebrafish

Efficient clofilium tosylate-mediated rescue of POLG-related disease phenotypes in zebrafish

Abstract The DNA polymerase gamma (Polg) is a nuclear-encoded enzyme involved in DNA replication in animal mitochondria. In humans, mutations in the POLG gene underlie a set of mitochondrial diseases characterized by mitochondrial DNA (mtDNA) depletion or deletion and multiorgan defects, named POLG...

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Main Authors: Nicola Facchinello, Claudio Laquatra, Lisa Locatello, Giorgia Beffagna, Raquel Brañas Casas, Chiara Fornetto, Alberto Dinarello, Laura Martorano, Andrea Vettori, Giovanni Risato, Rudy Celeghin, Giacomo Meneghetti, Massimo Mattia Santoro, Agnes Delahodde, Francesco Vanzi, Andrea Rasola, Luisa Dalla Valle, Maria Berica Rasotto, Tiziana Lodi, Enrico Baruffini, Francesco Argenton, Natascia Tiso
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-020-03359-z

Internet

https://doi.org/10.1038/s41419-020-03359-z

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