EGR2-mediated regulation of m6A reader IGF2BP proteins drive RCC tumorigenesis and metastasis via enhancing S1PR3 mRNA stabilization

EGR2-mediated regulation of m6A reader IGF2BP proteins drive RCC tumorigenesis and metastasis via enhancing S1PR3 mRNA stabilization

Abstract Emerging discoveries of dynamic and reversible N6-methyladenosine (m6A) modification on RNA in mammals have revealed the key roles of the modification in human tumorigenesis. As known m6A readers, insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs) are upregulated in most cancers a...

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Bibliographic Details
Main Authors: Yufan Ying, Xueyou Ma, Jiajie Fang, Shiming Chen, Weiyu Wang, Jiangfeng Li, Haiyun Xie, Jian Wu, Bo Xie, Ben Liu, Xiao Wang, Xiangyi Zheng, Liping Xie
Format: Article
Language:English
Published: Nature Publishing Group 2021-07-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-021-04038-3

Internet

https://doi.org/10.1038/s41419-021-04038-3

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