The kinematics of cytotoxic lymphocytes influence their ability to kill target cells.

Cytotoxic lymphocytes (CTL) have been reported to show a range of motility patterns from rapid long-range tracking to complete arrest, but how and whether these kinematics affect their ability to kill target cells is not known. Many in vitro killing assays utilize cell lines and tumour-derived cells...

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Bibliographic Details
Main Authors: Purnima Bhat, Graham Leggatt, Klaus I Matthaei, Ian H Frazer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4011687?pdf=render