Flavokawain B and Doxorubicin Work Synergistically to Impede the Propagation of Gastric Cancer Cells via ROS-Mediated Apoptosis and Autophagy Pathways

Flavokawain B and Doxorubicin Work Synergistically to Impede the Propagation of Gastric Cancer Cells via ROS-Mediated Apoptosis and Autophagy Pathways

Chalcone flavokawain B (FKB) possesses a chemopreventive and anti-cancer activity. Doxorubicin is a chemotherapeutic DNA intercalating agent widely used in malignancy treatment. The present study investigated whether synergistic effects exist between the combination of FKB (1.25–5 µg/mL) and doxorub...

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Bibliographic Details
Main Authors: You-Cheng Hseu, Ruei-Wan Lin, Yi-Chun Shen, Kai-Yuan Lin, Jiunn-Wang Liao, Varadharajan Thiyagarajan, Hsin-Ling Yang
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Cancers
Subjects:
flavokawain B
doxorubicin
apoptosis
autophagy
ROS
Online Access:https://www.mdpi.com/2072-6694/12/9/2475

Internet

https://www.mdpi.com/2072-6694/12/9/2475

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