Induction of amyloid-β deposits from serially transmitted, histologically silent, Aβ seeds issued from human brains

Induction of amyloid-β deposits from serially transmitted, histologically silent, Aβ seeds issued from human brains

Abstract In humans, iatrogenic transmission of cerebral amyloid-β (Aβ)-amyloidosis is suspected following inoculation of pituitary-derived hormones or dural grafts presumably contaminated with Aβ proteins as well as after cerebral surgeries. Experimentally, intracerebral inoculation of brain homogen...

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Bibliographic Details
Main Authors: Anne-Sophie Hérard, Fanny Petit, Charlotte Gary, Martine Guillermier, Susana Boluda, Clément M. Garin, The Brainbank Neuro-CEB Neuropathology Network, Suzanne Lam, Marc Dhenain
Format: Article
Language:English
Published: BMC 2020-11-01
Series:Acta Neuropathologica Communications
Subjects:
β-amyloid pathology
Alzheimer’s disease
Aβ transmission
Online Access:https://doi.org/10.1186/s40478-020-01081-7

Internet

https://doi.org/10.1186/s40478-020-01081-7

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