In vitro modeling of the neurovascular environment by coculturing adult human brain endothelial cells with human neural stem cells.

Brain and vascular cells form a functionally integrated signalling network that is known as the neurovascular unit (NVU). The signalling (autocrine, paracrine and juxtacrine) between different elements of this unit, especially in humans, is difficult to disentangle in vivo. Developing representative...

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Bibliographic Details
Main Authors: Chung-Hsing Chou, John D Sinden, Pierre-Olivier Couraud, Michel Modo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4154686?pdf=render