Chronic Sulfasalazine Treatment in Mice Induces System xc− - Independent Adverse Effects

Chronic Sulfasalazine Treatment in Mice Induces System xc− - Independent Adverse Effects

Despite ample evidence for the therapeutic potential of inhibition of the cystine/glutamate antiporter system xc− in neurological disorders and in cancer, none of the proposed inhibitors is selective. In this context, a lot of research has been performed using the EMA- and FDA-approved drug sulfasal...

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Bibliographic Details
Main Authors: Lise Verbruggen, Lindsay Sprimont, Eduard Bentea, Pauline Janssen, Azzedine Gharib, Lauren Deneyer, Laura De Pauw, Olaya Lara, Hideyo Sato, Charles Nicaise, Ann Massie
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Pharmacology
Subjects:
system xc−
sulfasalazine
adverse (side) effects
spinal cord
behavior
cystine
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.625699/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.625699/full

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