Anti-Trypanosomal Proteasome Inhibitors Cure Hemolymphatic and Meningoencephalic Murine Infection Models of African Trypanosomiasis

Anti-Trypanosomal Proteasome Inhibitors Cure Hemolymphatic and Meningoencephalic Murine Infection Models of African Trypanosomiasis

Current anti-trypanosomal therapies suffer from problems of longer treatment duration, toxicity and inadequate efficacy, hence there is a need for safer, more efficacious and ‘easy to use’ oral drugs. Previously, we reported the discovery of the triazolopyrimidine (TP) class as s...

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Bibliographic Details
Main Authors: Srinivasa P S Rao, Suresh B Lakshminarayana, Jan Jiricek, Marcel Kaiser, Ryan Ritchie, Elmarie Myburgh, Frantisek Supek, Tove Tuntland, Advait Nagle, Valentina Molteni, Pascal Mäser, Jeremy C Mottram, Michael P Barrett, Thierry T Diagana
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Tropical Medicine and Infectious Disease
Subjects:
sleeping sickness
drug discovery
<i>trypanosoma</i> growth inhibitors
Online Access:https://www.mdpi.com/2414-6366/5/1/28

Internet

https://www.mdpi.com/2414-6366/5/1/28

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