Effects of long-term culture on the biological characteristics and RNA profiles of human bone-marrow-derived mesenchymal stem cells

Effects of long-term culture on the biological characteristics and RNA profiles of human bone-marrow-derived mesenchymal stem cells

Expansion in vitro prior to mesenchymal stem cells (MSCs) application is a necessary process. Functional and genomic stability has a crucial role in stem-cell-based therapies. However, the exact expression and co-expressed profiles of coding and non-coding RNAs in human bone marrow (BM)-MSCs in vitr...

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Bibliographic Details
Main Authors: Shan Wang, Ziming Wang, Hongjun Su, Fenglei Chen, Mengjun Ma, Wenhui Yu, Guiwen Ye, Shuizhong Cen, Rujia Mi, Xiaohua Wu, Wen Deng, Pei Feng, Chenying Zeng, Huiyong Shen, Yanfeng Wu
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
MSCs
passage
in vitro aging
RNA-seq
lncRNAs
circRNAs
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253121002079

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http://www.sciencedirect.com/science/article/pii/S2162253121002079

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