Rapid end-point quantitation of prion seeding activity with sensitivity comparable to bioassays.

Rapid end-point quantitation of prion seeding activity with sensitivity comparable to bioassays.

A major problem for the effective diagnosis and management of prion diseases is the lack of rapid high-throughput assays to measure low levels of prions. Such measurements have typically required prolonged bioassays in animals. Highly sensitive, but generally non-quantitative, prion detection method...

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Bibliographic Details
Main Authors: Jason M Wilham, Christina D Orrú, Richard A Bessen, Ryuichiro Atarashi, Kazunori Sano, Brent Race, Kimberly D Meade-White, Lara M Taubner, Andrew Timmes, Byron Caughey
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-12-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC2996325?pdf=render

Internet

http://europepmc.org/articles/PMC2996325?pdf=render

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