Acrolein scavenger dimercaprol offers neuroprotection in an animal model of Parkinson’s disease: implication of acrolein and TRPA1

Acrolein scavenger dimercaprol offers neuroprotection in an animal model of Parkinson’s disease: implication of acrolein and TRPA1

Abstract Background The mechanisms underlying lesions of dopaminergic (DA) neurons, an essential pathology of Parkinson’s disease (PD), are largely unknown, although oxidative stress is recognized as a key factor. We have previously shown that the pro-oxidative aldehyde acrolein is a critical factor...

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Bibliographic Details
Main Authors: Liangqin Shi, Yazhou Lin, Yucheng Jiao, Seth A. Herr, Jonathan Tang, Edmond Rogers, Zhengli Chen, Riyi Shi
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Translational Neurodegeneration
Subjects:
Oxidative stress
Parkinson’s disease
Neuroinflammation
Acrolein
TRPA1
Dimercaprol
Online Access:https://doi.org/10.1186/s40035-021-00239-0

Internet

https://doi.org/10.1186/s40035-021-00239-0

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