SFlt-1 elevates blood pressure by augmenting endothelin-1-mediated vasoconstriction in mice.

SFlt-1 elevates blood pressure by augmenting endothelin-1-mediated vasoconstriction in mice.

OBJECTIVE: Scavenging of vascular endothelial growth factor (VEGF) elevates blood pressure (BP) in patients receiving anti-angiogenic therapy. Similarly, inhibition of circulation VEGF by its soluble receptor fms-like tyrosine kinase-1 (sFlt-1) underlies BP elevation in pre-eclampsia. Both phenotype...

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Bibliographic Details
Main Authors: Fouad Amraoui, Léon Spijkers, Hajar Hassani Lahsinoui, Liffert Vogt, Joris van der Post, Stephan Peters, Gijs Afink, Carrie Ris-Stalpers, Bert-Jan van den Born
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3954828?pdf=render

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http://europepmc.org/articles/PMC3954828?pdf=render

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