The anti-cancer effects of itraconazole in epithelial ovarian cancer

The anti-cancer effects of itraconazole in epithelial ovarian cancer

Abstract We assessed the anti-proliferative activity of itraconazole using an EOC cell line (SKOV3ip1) and endothelial cell lines (HUVEC & SVEC4-10). We also examined angiogenesis (VEGFR2, p-ERK, p-PLCr1/2), hedgehog (Gli1, Ptch1, SMO), and mTOR (pS6K1) signaling pathways to determine the mechan...

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Main Authors: Chel Hun Choi, Ji-Yoon Ryu, Young-Jae Cho, Hye-Kyung Jeon, Jung-Joo Choi, Kris Ylaya, Yoo-Young Lee, Tae-Joong Kim, Joon-Yong Chung, Stephen M. Hewitt, Byoung-Gie Kim, Duk-Soo Bae, Jeong-Won Lee
Format: Article
Language:English
Published: Nature Publishing Group 2017-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-06510-7

Internet

https://doi.org/10.1038/s41598-017-06510-7

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