Reduced TORC1 signaling abolishes mitochondrial dysfunctions and shortened chronological lifespan of Isc1p-deficient cells

Reduced TORC1 signaling abolishes mitochondrial dysfunctions and shortened chronological lifespan of Isc1p-deficient cells

The target of rapamycin (TOR) is an important signaling pathway on a hierarchical network of interacting pathways regulating central biological processes, such as cell growth, stress response and aging. Several lines of evidence suggest a functional link between TOR signaling and sphingolipid metabo...

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Bibliographic Details
Main Authors: Vitor Teixeira, Tânia C. Medeiros, Rita Vilaça, Pedro Moradas-Ferreira, Vítor Costa
Format: Article
Language:English
Published: Shared Science Publishers OG 2014-01-01
Series:Microbial Cell
Subjects:
Isc1p
Tor1p
Sch9p
oxidative stress
chronological aging
mitochondrial function
ROS
ceramide
Online Access:http://microbialcell.com/researcharticles/reduced-torc1-signaling-abolishes-mitochondrial-dysfunctions-shortened-chronological-lifespan-isc1p-deficient-cells/

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http://microbialcell.com/researcharticles/reduced-torc1-signaling-abolishes-mitochondrial-dysfunctions-shortened-chronological-lifespan-isc1p-deficient-cells/

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