High-level extracellular production of recombinant nattokinase in Bacillus subtilis WB800 by multiple tandem promoters

High-level extracellular production of recombinant nattokinase in Bacillus subtilis WB800 by multiple tandem promoters

Abstract Background Nattokinase (NK), which is a member of the subtilisin family, is a potent fibrinolytic enzyme that might be useful for thrombosis therapy. Extensive work has been done to improve its production for the food industry. The aim of our study was to enhance NK production by tandem pro...

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Bibliographic Details
Main Authors: Zhongmei Liu, Wenhui Zheng, Chunlei Ge, Wenjing Cui, Li Zhou, Zhemin Zhou
Format: Article
Language:English
Published: BMC 2019-05-01
Series:BMC Microbiology
Subjects:
Nattokinase
Tandem promoter
Core promoter region
Bacillus subtilis
Recombinant enzyme
Online Access:http://link.springer.com/article/10.1186/s12866-019-1461-3

Internet

http://link.springer.com/article/10.1186/s12866-019-1461-3

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