Pharmacokinetic Interaction of Green Rooibos Extract With Atorvastatin and Metformin in Rats

Pharmacokinetic Interaction of Green Rooibos Extract With Atorvastatin and Metformin in Rats

An aspalathin-rich green rooibos extract (Afriplex GRT™) has demonstrated anti-diabetic and hypolipidemic properties, while also moderately inhibiting CYP3A4 activity, suggesting a potential for herb–drug interaction. The present study, therefore, evaluated the effects of orally administered GRT on...

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Bibliographic Details
Main Authors: Oelfah Patel, Christo J.F. Muller, Elizabeth Joubert, Bernd Rosenkranz, Malcolm J.C. Taylor, Johan Louw, Charles Awortwe
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Pharmacology
Subjects:
rooibos
atorvastatin
transporters
Wistar
rats
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01243/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.01243/full

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