Administration of cardiac mesenchymal cells modulates innate immunity in the acute phase of myocardial infarction in mice

Abstract Although cardiac mesenchymal cell (CMC) therapy mitigates post-infarct cardiac dysfunction, the underlying mechanisms remain unidentified. It is acknowledged that donor cells are neither appreciably retained nor meaningfully contribute to tissue regeneration—suggesting a paracrine-mediated...

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Bibliographic Details
Main Authors: Yi Kang, Marjan Nasr, Yiru Guo, Shizuka Uchida, Tyler Weirick, Hong Li, Jae Kim, Joseph B. Moore, Senthilkumar Muthusamy, Roberto Bolli, Marcin Wysoczynski
Format: Article
Language:English
Published: Nature Publishing Group 2020-09-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-020-71580-z