HMGB1 Activates Proinflammatory Signaling via TLR5 Leading to Allodynia

HMGB1 Activates Proinflammatory Signaling via TLR5 Leading to Allodynia

Infectious and sterile inflammatory diseases are correlated with increased levels of high mobility group box 1 (HMGB1) in tissues and serum. Extracellular HMGB1 is known to activate Toll-like receptors (TLRs) 2 and 4 and RAGE (receptor for advanced glycation endproducts) in inflammatory conditions....

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Bibliographic Details
Main Authors: Nabanita Das, Varun Dewan, Peter M. Grace, Robin J. Gunn, Ryo Tamura, Netanel Tzarum, Linda R. Watkins, Ian A. Wilson, Hang Yin
Format: Article
Language:English
Published: Elsevier 2016-10-01
Series:Cell Reports
Subjects:
Toll-like receptors
HMGB1
inflammation
cytokines
pain
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716313328

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http://www.sciencedirect.com/science/article/pii/S2211124716313328

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