Hypoxia preconditioning promotes cardiac stem cell survival and cardiogenic differentiation in vitro involving activation of the HIF-1α/apelin/APJ axis

Hypoxia preconditioning promotes cardiac stem cell survival and cardiogenic differentiation in vitro involving activation of the HIF-1α/apelin/APJ axis

Abstract Background Cardiac stem cells (CSCs) transplantation has been regarded as an optimal therapeutic approach for cardiovascular disease. However, inferior survival and low differentiation efficiency of these cells in the local infarct site reduce their therapeutic efficacy. In this study, we i...

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Bibliographic Details
Main Authors: Jingying Hou, Lei Wang, Huibao Long, Hao Wu, Quanhua Wu, Tingting Zhong, Xuxiang Chen, Changqing Zhou, Tianzhu Guo, Tong Wang
Format: Article
Language:English
Published: BMC 2017-09-01
Series:Stem Cell Research & Therapy
Subjects:
Hypoxia preconditioning
Cardiac stem cells
HIF-1α
Apelin/APJ
Survival
Cardiogenic differentiation
Online Access:http://link.springer.com/article/10.1186/s13287-017-0673-4

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http://link.springer.com/article/10.1186/s13287-017-0673-4

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