Differential roles of PML isoforms

Differential roles of PML isoforms

The tumor suppressor promyelocytic leukemia protein (PML) is fused to the retinoic acid receptor alpha in patients suffering from acute promyelocytic leukemia (APL). Treatment of APL patients with arsenic trioxide (As2O3) reverses the disease phenotype by a process involving the degradation of the f...

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Bibliographic Details
Main Authors: Sébastien eNisole, Mohamed Ali eMaroui, Xavier eMascle, Muriel eAubry, Mounira K Chelbi-Alix
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-05-01
Series:Frontiers in Oncology
Subjects:
virus
SUMO
RNF4
CK2
TRIM
PML isoforms
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00125/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00125/full

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