Genomic Heterogeneity and Clonal Evolution in Gastroesophageal Junction Cancer Revealed by Single Cell DNA Sequencing

Genomic Heterogeneity and Clonal Evolution in Gastroesophageal Junction Cancer Revealed by Single Cell DNA Sequencing

Gastroesophageal junction (GEJ) cancer is a tumor that occurs at the junction of stomach and esophagus anatomically. GEJ cancer frequently metastasizes to lymph nodes, however the heterogeneity and clonal evolution process are unclear. This study is the first of this kind to use single cell DNA sequ...

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Bibliographic Details
Main Authors: Qingke Duan, Chao Tang, Zhao Ma, Chuangui Chen, Xiaobin Shang, Jie Yue, Hongjing Jiang, Yan Gao, Bo Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Oncology
Subjects:
single cell sequencing
gastroesophageal junction cancer
genomic heterogeneity
clonal evolution
metastasis
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.672020/full

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https://www.frontiersin.org/articles/10.3389/fonc.2021.672020/full

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