Interferon-Independent Upregulation of Interferon-Stimulated Genes during Human Cytomegalovirus Infection is Dependent on IRF3 Expression

Interferon-Independent Upregulation of Interferon-Stimulated Genes during Human Cytomegalovirus Infection is Dependent on IRF3 Expression

The antiviral activity of type I interferons (IFNs) is primarily mediated by interferon-stimulated genes (ISGs). Induction of ISG transcription is achieved when type I IFNs bind to their cognate receptor and activate the Janus Kinase/Signal Transducer and Activator of Transcription (JAK/STAT) signal...

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Bibliographic Details
Main Authors: Caroline L. Ashley, Allison Abendroth, Brian P. McSharry, Barry Slobedman
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Viruses
Subjects:
interferon
human cytomegalovirus
IRF3
ISG15
interferon stimulated genes
Online Access:http://www.mdpi.com/1999-4915/11/3/246

Internet

http://www.mdpi.com/1999-4915/11/3/246

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