Phase 1 Study Evaluating the Association of the Cyclin-Dependent Kinase 4/6 Inhibitor Ribociclib and Cetuximab in Recurrent/Metastatic p16-Negative Squamous Cell Carcinoma of the Head and Neck

Phase 1 Study Evaluating the Association of the Cyclin-Dependent Kinase 4/6 Inhibitor Ribociclib and Cetuximab in Recurrent/Metastatic p16-Negative Squamous Cell Carcinoma of the Head and Neck

Background: The majority of human papillomavirus (HPV)-negative squamous cell carcinoma of the head and neck (SCCHN) present upregulation of the epidermal growth factor receptor (EGFR) and frequent alterations in the cyclin D1-cyclin dependent kinase (CDK) 4/6 (CDK 4/6)-retinoblastoma protein (pRb)...

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Bibliographic Details
Main Authors: Emmanuel Seront, Sandra Schmitz, Matthias Papier, Aline van Maanen, Stéphanie Henry, Christophe Lonchay, Sylvie Rottey, Gabrielle van Caloen, Jean-Pascal Machiels
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Oncology
Subjects:
ribociclib
cetuximab
HPV
recurrent
squamous cell carcinoma
head and neck
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.00155/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2019.00155/full

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