The Contorsbody, an antibody format for agonism: Design, structure, and function

The Contorsbody, an antibody format for agonism: Design, structure, and function

The careful design of the antibody architecture is becoming more and more important, especially when the purpose is agonism. We present the design of a novel antibody format that is able to promote receptor dimerization and induce signal transduction resulting in cell proliferation. Mono-specific bi...

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Bibliographic Details
Main Authors: Guy J. Georges, Stefan Dengl, Alexander Bujotzek, Friederike Hesse, Jens A.A. Fischer, Achim Gärtner, Jörg Benz, Matthias E. Lauer, Philippe Ringler, Henning Stahlberg, Friederike Plath, Ulrich Brinkmann, Sabine Imhof-Jung
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Antibody format
Molecular modeling
Receptor dimerization
Protein engineering
Electron microscopy
Molecular dynamic
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037020302701

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http://www.sciencedirect.com/science/article/pii/S2001037020302701

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