Inhibition of HIF2alpha is sufficient to suppress pVHL-defective tumor growth.
Biallelic inactivation of the von Hippel-Lindau tumor suppressor gene (VHL) is linked to the development of hereditary (VHL-associated) and sporadic clear-cell renal carcinomas as well as other abnormalities. The VHL gene product, pVHL, is part of an E3 ubiquitin ligase complex that targets the alph...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2003-12-01
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| Series: | PLoS Biology |
| Online Access: | http://europepmc.org/articles/PMC300692?pdf=render |