TLR2 and caspase-1 signaling are critical for bacterial containment but not clearance during craniotomy-associated biofilm infection

TLR2 and caspase-1 signaling are critical for bacterial containment but not clearance during craniotomy-associated biofilm infection

Abstract Background A craniotomy is required to access the brain for tumor resection or epilepsy treatment, and despite precautionary measures, infectious complications occur at a frequency of 1–3%. Approximately half of craniotomy infections are caused by Staphylococcus aureus (S. aureus) that form...

Full description

Bibliographic Details
Main Authors: Amy L. Aldrich, Cortney E. Heim, Wen Shi, Rachel W. Fallet, Bin Duan, Tammy Kielian
Format: Article
Language:English
Published: BMC 2020-04-01
Series:Journal of Neuroinflammation
Subjects:
Craniotomy
S. aureus
Biofilm
Toll-like receptor
Caspase-1
IL-1β
Online Access:http://link.springer.com/article/10.1186/s12974-020-01793-6

Internet

http://link.springer.com/article/10.1186/s12974-020-01793-6

Similar Items