C5a-Preactivated Neutrophils Are Critical for Autoimmune-Induced Astrocyte Dysregulation in Neuromyelitis Optica Spectrum Disorder

C5a-Preactivated Neutrophils Are Critical for Autoimmune-Induced Astrocyte Dysregulation in Neuromyelitis Optica Spectrum Disorder

Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune neuroinflammatory disease. In contrast to multiple sclerosis, autoantibodies against aquaporin-4 (AQP4) expressed on astrocytic end-feet have been exclusively detected in sera of NMOSD patients. Several lines of evidence suggested that...

Full description

Bibliographic Details
Main Authors: Paweł Piatek, Małgorzata Domowicz, Natalia Lewkowicz, Patrycja Przygodzka, Mariola Matysiak, Katarzyna Dzitko, Przemysław Lewkowicz
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Immunology
Subjects:
astrocytes
neutrophils
complement system
glutamate
neuromyelitis optica spectrum disorder
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01694/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01694/full

Similar Items