The invadopodia scaffold protein Tks5 is required for the growth of human breast cancer cells in vitro and in vivo.

The invadopodia scaffold protein Tks5 is required for the growth of human breast cancer cells in vitro and in vivo.

The ability of cancer cells to invade underlies metastatic progression. One mechanism by which cancer cells can become invasive is through the formation of structures called invadopodia, which are dynamic, actin-rich membrane protrusions that are sites of focal extracellular matrix degradation. Whil...

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Bibliographic Details
Main Authors: Barbara Blouw, Manishha Patel, Shinji Iizuka, Christopher Abdullah, Weon Kyoo You, Xiayu Huang, Jian-Liang Li, Begoña Diaz, William B Stallcup, Sara A Courtneidge
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4380437?pdf=render

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http://europepmc.org/articles/PMC4380437?pdf=render

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